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Running Header: ASSIGNMENT TITLE1Assignment TitleStudent NameUniversity: Course NameDateInstructor NameASSIGNMENT TITLE2Title of the Assignment1. The oxygen binding affinity of hemoglobin is one of the primary mechanisms forincreasing the circulatory conductance of oxygen in high-altitude mammals. The oxygen,whichhasreducedresponsivenesstowardsorganicphosphatessuchas2,3biphosphoglycerate that stabilizes the low affinity, deoxygenated conformation ofhemoglobin. So, the stage of oxygen diffusion into the blood after which the oxygen is takento all the parts of the body shows the greatest impact of haemoglobin change in mammalsadapted to high altitude versus those adapted to lower altitudes. Modification of Hb functionmay play a key role in mediating an adaptive response to high altitude hypoxia. The higheraltitude mammals are found to have higher ...


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