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Kaileen Hendle04/11/17Writing Assignment 3: Loperamide for DiarrheaDiarrhea being expelled from the body is not normal. This indicates that there is an issue within the gastrointestinal tract. Normally the small intestine absorbs most of the water in chyme. Approximately 95% of water is absorbed in the small intestine by osmosis (Marieb, 2014). The remaining water is usually absorbed in the large intestine, and some is even used to help soften the stool that is supposed to be pushed out. Peristalsis and segmentation in the small intestine helps mucosal cells absorb the water within the chyme. According to Marieb (2014), water moves freely in both directions of the intestinal mucosa, and active transport of solutes into the mucosal cells creates net osmosis because of the concentration gradient established. Therefore, water uptake is paired to solute uptake, and then affects the absorption of substances that …show more content…
This will allow more water to be absorbed so that the stool is not watery. Loperamide is an opioid receptor agonist (Case-Lo, 2011). Therefore, it increases the stimulation of opioid receptors within the gastrointestinal tract. The drug stimulates opioid receptors to slow segmentation and peristalsis, and to increase the reuptake of water by the mucosal cells. It does this by delaying transit of chyme and increasing the contact time along the intestinal wall so more absorption can take place. This happens by decreasing circular and longitudinal muscle contractions that allows for peristalsis and segmentation to occur (Case-Lo, 2017). It then stimulates mucosal sensory receptors which activate a reflex arc that further facilitates further fluid absorption (Case-Lo, 2011). Mucosal cells will then start to absorb the water and create the concentration gradients again so that other substances will follow with. This will leave the feces less watery and help make is more solid for

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