Introduction1.1
Prevalence and pathogenesis of chronic heart failureChronic heart
failure (CHF), a potentially fatal stage of any cardiovascular
disease not only demonstrates a steady growth in the general
population, but also the significant economic costs of the health
system in improving the clinical status of patients, improving
their quality of life, reduce the risk of adverse clinical outcomes
(Mosterd A., Hoes AW 2007 McMurry JJ, 2010). The European
Guidelines for the diagnosis and treatment of CHF, determines the
CHF, as the "pathophysiologic syndrome, in which the result of a
disease of the cardiovascular system is reduced pumping function,
which leads to an imbalance between the hemodynamic needs of the
body and the heart needs" [16].CHF suffers 1.5-2% of the world's
population [74]. The prevalence of CHF in the European population
reaches 2.0%, in US - 2.2%, and in Russia - 6% and significantly
increases with age [34, 63]. Currently, the number of patients with
heart failure is increasing in all developed countries. This is due
to an increase in survival in patients with cardiovascular disease,
in particular, acute coronary syndrome, and thus objectively
predisposed to the development of heart failure, as well as the
steady trend to an increase in the population share of older age
groups [79,
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Recent studies
conducted in the US showed that the most common cause of heart
failure is also hypertension in combination with ischemic heart
disease or without it. Euro Heart Survey Study, conducted in 2001,
analyzed the share etiologic CHF factors: the most common cause of
this condition in Europe is coronary artery disease - 60%, valvular
heart disease - 14%, dilated cardiomyopathy (DCM) - 11%,
hypertension - 4 % of







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